Medical Safety Guide
Compound Tirzepatide Safety Information
This document provides an overview of important safety considerations related to EVOLVD’s compounded Tirzepatide formulations, including Tirzepatide + Pyridoxine (B6) and Tirzepatide + Methylcobalamin (B12). Compounded medications are permitted to be prescribed under federal law but are not FDA-approved, and they do not undergo FDA review for safety, effectiveness, or manufacturing standards. Your prescribing provider will determine whether compounded Tirzepatide is appropriate for you based on your medical evaluation.
This summary does not contain all possible safety information and does not replace guidance from your licensed medical provider.
Indications and Use
Compounded Tirzepatide is an injectable prescription medication used as part of a comprehensive medical weight management program. It may support weight reduction and long-term weight maintenance in adults with:
• A BMI of 30 kg/m² or higher, or
• A BMI of 27 kg/m² or higher with a weight-related condition (such as hypertension, dyslipidemia, prediabetes, type 2 diabetes, or sleep apnea)
Compounded Tirzepatide is a dual-acting GLP-1/GIP receptor agonist. It is used in combination with balanced nutrition, calorie reduction, and increased physical activity.
Compounded Tirzepatide should not be combined with any other GLP-1 medications, including brand-name products or other compounded GLP-1/GIP formulations. It is not known whether compounded Tirzepatide is safe or effective in individuals under age 18, or in individuals with a history of pancreatitis.
About EVOLVD’s Tirzepatide Formulations
EVOLVD offers two compounded variants:
• Tirzepatide + Pyridoxine (Vitamin B6)
May support nausea reduction and metabolic health.
• Tirzepatide + Methylcobalamin (Vitamin B12)
May support energy, mood stability, and healthy red-blood-cell function.
These vitamins are added by the compounding pharmacy but do not change the fundamental mechanism or standard safety profile of Tirzepatide.
Important Safety Information
Thyroid C-Cell Tumor Warning
In rodent studies, Tirzepatide caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). It is unknown if this risk applies to humans.
You should not use compounded Tirzepatide if:
• You or a family member has had MTC
• You have Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
• You notice neck lumps, hoarseness, difficulty swallowing, or unexplained shortness of breath\
Limitations of Use
• Not to be used with any other GLP-1 or GIP medications
• Not studied in individuals with past or current pancreatitis
• Not approved for use during pregnancy or breastfeeding
• Not approved by the U.S. Food and Drug Administration (FDA)
Compounded medications do not carry the same FDA-established indications or testing standards as brand-name drugs.
Who Should Not Use Compounded Tirzepatide
Avoid compounded Tirzepatide if you:
• Have a personal or family history of MTC
• Have MEN2
• Are allergic to Tirzepatide or any formulation ingredients
• Are pregnant or planning a pregnancy
• Are breastfeeding
• Are currently using another GLP-1 or GIP medication
• Have uncontrolled gastrointestinal disorders that worsen with delayed gastric emptying
How to Administer Compounded Tirzepatide
Compounded Tirzepatide is administered using a vial and syringe as a subcutaneous injection into:
• The abdomen
• Thigh
• Upper arm
It is taken once weekly, on the same day each week. Your provider may adjust your dose approximately every four weeks based on your response and tolerance.
Do not change your dosing schedule without provider approval.
What to Tell Your Medical Provider Before Starting
Be sure to disclose:
• All prescription and over-the-counter medications
• Herbal supplements
• Vitamins
• Any previous history of GLP-1 use
• All current and past weight-loss medications
Especially important drug interactions:
• Insulin and sulfonylureas (may increase risk of low blood sugar)
• Oral medications requiring predictable absorption (GLP-1 meds delay gastric emptying)
• Hormonal birth control pills (effectiveness may be reduced after starting or increasing the dose)
Share your full medical history, particularly if you have ever had:
• Type 1 or type 2 diabetes
• Thyroid disease
• Pancreatitis
• Gallbladder disease
• Kidney disease
• Diabetic retinopathy
• Autoimmune disorders
• Depression or suicidal thoughts
• Severe gastrointestinal disorders
Pregnancy & Fertility
Tirzepatide should not be used if you are pregnant or planning pregnancy. It should be discontinued at least two months before attempting to conceive.
It is unknown whether Tirzepatide passes into breast milk.
Providing inaccurate medical information may result in harm
Most Serious Side Effects
If you experience any emergency symptoms, call 911.
Monitor for:
• Persistent or severe abdominal pain (possible pancreatitis)
• Severe nausea and vomiting leading to dehydration
• Yellowing of skin or eyes (possible gallbladder disease)
• Rapid heartbeat at rest
• Vision changes
• Suicidal thoughts, mood changes, or unusual behavior
• Symptoms of allergic reactions (facial swelling, rash, breathing difficulty)
Never share injection supplies with another person.
Common Side Effects
Side effects are usually mild and improve over time. These may include:
• Nausea or vomiting
• Diarrhea or constipation
• Bloating or gas
• Reflux or indigestion
• Stomach discomfort
• Fatigue
• Mild headache
• Dizziness
• Injection-site redness or itching
• Belching
• Hair shedding
• Reduced appetite
Contact your provider if symptoms become severe or persistent.
Report adverse reactions to the FDA at 1-800-FDA-1088.
Before Using Compounded Tirzepatide
Review with your provider:
• Any history of kidney disease or dehydration
• Any gastrointestinal issues
• All diabetes medications
• Use of birth-control pills
• Any previous reactions to injectable therapies
Read all pharmacy-provided instructions before your first dose.
How to Take Compounded Tirzepatide
General administration guidance:
• Use exactly as prescribed
• Inject once weekly
• Rotate injection sites
• Follow storage instructions on the vial
• Contact your provider immediately if too much medication is taken
Oral forms, if prescribed, follow a different dosing schedule that your provider will specify.
Legal and Safety Disclosure
Compounded Tirzepatide is not approved by the FDA.
The FDA does not evaluate compounded medications for safety, effectiveness, or quality.
Brand names referenced for comparison (such as Mounjaro®, Zepbound®, Ozempic®, Wegovy®, and Saxenda®) are the property of their respective manufacturers. EVOLVD is not affiliated with these companies, and compounded Tirzepatide is not produced by them.
Service-Specific Safety Information
Below is a detailed overview of safety expectations for each service offered at EVOLVD. Not all services that are listed below will be offered at each Evolvd location.
Microneedling – Safety Information
Microneedling is a minimally invasive aesthetic procedure performed under delegated medical oversight due to the use of controlled devices that penetrate the skin.
Clients may experience temporary redness, swelling, pinpoint bleeding, or mild irritation. Not all individuals are candidates, particularly those with:
• Active acne
• Open wounds
• Autoimmune conditions
• Blood-thinning medications
• Recent sunburn or chemical peels
• Pregnancy/breastfeeding
• Certain dermatologic disorders
All eligibility and treatment protocols are determined by our supervising clinician. EVOLVD staff perform the procedure only according to approved medical guidelines.
Dermaplaning – Safety Information
Dermaplaning involves gentle exfoliation of the top layer of dead skin and vellus hair. At EVOLVD, dermaplaning beyond basic cosmetic limits may be performed under medical delegation.
Possible temporary reactions include redness, sensitivity, or mild irritation. This service is not recommended for clients with:
• Active acne
• Open skin lesions
• Rosacea flares
• Certain skin sensitivities
Dermaplaning does not diagnose, treat, or cure any medical condition. Any medical concerns are referred to the supervising medical provider.
EMS + RF Body Contouring – Safety Information
This non-invasive body contouring treatment uses controlled electrical stimulation and radiofrequency energy. Because this involves energy-based equipment, all services are performed under delegated medical oversight.
Results vary and are influenced by hydration, lifestyle, body composition, and adherence to aftercare. The treatment is not intended for weight loss and does not replace medical care.
Not suitable for individuals with:
• Pacemakers or implanted medical devices
• Metal implants
• Pregnancy
• Active cancer
• Recent surgical procedures
• Neurological or cardiac disorders
Temporary effects may include warmth, redness, swelling, or muscle fatigue.
Red Light Facial Therapy – Safety Information
Red light therapy is a non-medical aesthetic wellness service designed to support skin appearance and cellular recovery.
Results differ among clients. Not recommended for individuals who:
• Have photosensitivity
• Take photosensitizing medications
• Have active infections or open wounds
This service does not diagnose or treat medical conditions.
Firm & Lift Facial – Safety Information
The Firm & Lift facial is designed to improve the appearance of skin tone, texture, and hydration. It is a cosmetic treatment and is not intended to address medical concerns.
Temporary skin sensitivity or redness may occur. This service may not be suitable for individuals with certain allergies, skin conditions, or sensitivities.
Waxing – Safety Information
Waxing is a cosmetic hair removal service. Some clients may experience temporary redness, sensitivity, or minor irritation.
Not recommended for those who:
• Use topical retinoids
• Have recently had chemical peels
• Have sunburn
• Have extremely reactive or compromised skin
Waxing does not diagnose or treat any medical condition.
Not Medical Advice
Information provided on our website, service pages, or during general consultation is for educational and aesthetic purposes only.
All clinical evaluations, treatment determinations, and prescribing decisions are made exclusively by licensed medical professionals.
Questions or Concerns
If clients experience unexpected reactions or have medical concerns following treatment, they are instructed to contact EVOLVD immediately so that our supervising clinician can review and advise.
Compound Semaglutide Safety Information (EVOLVD)
This document outlines safety considerations for EVOLVD’s compounded Semaglutide formulations, including Semaglutide combined with Pyridoxine (B6) or Methylcobalamin (B12). Compounded medications may be prescribed under federal law; however, they are not FDA-approved and have not undergone FDA review for safety, effectiveness, or manufacturing quality. Your prescribing provider will determine whether compounded Semaglutide is appropriate based on your medical evaluation.
This summary does not contain all possible safety information and does not replace medical guidance from your licensed provider.
Indications and use
Compounded Semaglutide is prescribed as part of a comprehensive medical weight-management program. It may support appetite control, weight reduction, and long-term maintenance in adults with:
• A BMI of 30 kg/m² or higher, or
• A BMI of 27 kg/m² or higher with a weight-related condition (such as hypertension, dyslipidemia, prediabetes, insulin resistance, or sleep apnea)
Semaglutide is a GLP-1 receptor agonist used together with a reduced-calorie diet and increased physical activity. It should not be combined with any other GLP-1 medications, whether brand-name or compounded. The safety and effectiveness of compounded Semaglutide have not been established in people under 18 or in individuals with a history of pancreatitis.
About EVOLVD’s Semaglutide formulations
EVOLVD offers several compounded variations designed to support tolerability and metabolic well-being, including Semaglutide combined with either Pyridoxine (Vitamin B6) or Methylcobalamin (Vitamin B12). These additions may support comfort and energy but do not change the core safety profile of Semaglutide. Both injectable and orally dissolving tablet (ODT) versions may be available depending on provider recommendations.
Important safety information
In rodent studies, Semaglutide caused thyroid C-cell tumors, including medullary thyroid carcinoma (MTC). It is unknown whether this risk applies to humans. Compounded Semaglutide should not be used by individuals with a personal or family history of MTC or those with Multiple Endocrine Neoplasia syndrome type 2 (MEN2). Notify your provider if you experience neck swelling, hoarseness, difficulty swallowing, or unexplained shortness of breath.
Limitations of use
Compounded Semaglutide should not be used in combination with any other GLP-1 medication. It has not been studied in individuals with past or present pancreatitis and is not approved for use during pregnancy or breastfeeding. Compounded medications are not FDA-approved and do not carry FDA-established indications or testing standards.
Who should not use compounded Semaglutide
Avoid compounded Semaglutide if you are pregnant, planning pregnancy, breastfeeding, allergic to Semaglutide, or using another GLP-1 medication. This medication may not be appropriate for individuals with gastroparesis, severe gastrointestinal disorders, MEN2, or a history of medullary thyroid carcinoma.
How is compounded Semaglutide administered
Injectable compounded Semaglutide is given once weekly as a subcutaneous injection into the abdomen, thigh, or upper arm. Dosage may be increased over time based on response and provider guidance. The ODT version dissolves under the tongue or between the cheek and gum and follows a different dosing schedule provided by your clinician. Do not adjust your dose without medical approval.
What to tell your provider before starting
Inform your provider of all medications and supplements you use, including herbal products, vitamins, and previous or current weight-loss medications. Semaglutide slows gastric emptying and may affect absorption of oral medications. Special caution is required with insulin, sulfonylureas, or medications affected by delayed digestion. Oral contraceptives may be less effective during dose adjustments.
Disclose your full medical history, especially if you have ever had diabetes, thyroid issues, kidney disease, pancreatitis, gallbladder disease, gastroparesis, visual changes, depression, or suicidal thoughts.
Semaglutide should be discontinued at least two months before attempting pregnancy. It is unknown whether Semaglutide passes into breast milk.
Most serious side effects
Seek emergency medical attention if you develop severe abdominal pain (with or without vomiting), jaundice, sudden vision changes, rapid heartbeat, fainting, persistent vomiting or diarrhea, or signs of an allergic reaction such as rash, swelling of the face or throat, or breathing difficulty. Never share injection supplies.
Common side effects
Most side effects are mild and improve over time. These may include nausea, vomiting, diarrhea, constipation, stomach discomfort, bloating, fatigue, dizziness, headache, belching, heartburn, reduced appetite, hair shedding, or injection-site reactions. Contact your provider if symptoms become severe or persistent.
Side effects may be reported to the FDA at 1-800-FDA-1088.
Before using compounded Semaglutide
Discuss any history of kidney problems, retinopathy, gastrointestinal conditions, or diabetes medications with your provider. Review all prescription and over-the-counter medications, vitamins, and supplements. Follow all dosing instructions provided by the pharmacy and your clinician.
How to take compounded Semaglutide
Use compounded Semaglutide exactly as prescribed. Inject once weekly (or use ODT as directed), rotate injection sites, and store medication according to pharmacy instructions. Contact your clinician or poison control immediately if you take more than your prescribed dose.
Legal and safety disclosures
Compounded Semaglutide is not FDA-approved, and the FDA does not evaluate compounded formulations for safety, quality, or effectiveness. Brand-name drugs referenced for comparison (such as Wegovy®, Ozempic®, and Saxenda®) are the property of their respective manufacturers and are not affiliated with EVOLVD. Compounded Semaglutide is not prepared by these manufacturers.
Compound NAD⁺ Injection Safety Information
This document provides an overview of important safety considerations for EVOLVD’s compounded NAD⁺ (nicotinamide adenine dinucleotide) injectable formulations. Compounded medications may be prescribed under federal law; however, they are not FDA-approved and have not undergone FDA review for safety, effectiveness, or manufacturing quality. Your prescribing provider will determine whether compounded NAD⁺ is appropriate for you based on your medical evaluation.
This summary does not include all possible information and does not replace guidance from your licensed medical provider.
What NAD⁺ injections are used for
Compounded NAD⁺ is a prescription-only injectable solution used to support cellular energy, mitochondrial function, and metabolic optimization. NAD⁺ levels naturally decline with age, chronic stress, poor sleep, inflammation, and metabolic dysfunction. Supplementation may support:
• Increased cellular energy (ATP production)
• Enhanced cognitive clarity and concentration
• Improved mood and stress tolerance
• Support for weight management programs
• Reduced fatigue
• Improved recovery and endurance
• Healthy aging and metabolic repair
Some patients also use NAD⁺ alongside GLP-1 therapies to support energy and offset fatigue during early dose adjustments.
EVOLVD’s NAD⁺ formulations
EVOLVD offers NAD⁺ in two standard concentrations:
• NAD⁺ 500 mg/mL Injection
• NAD⁺ 1000 mg/mL Injection
Your provider will determine your starting protocol, frequency, and titration schedule based on your goals and tolerance.
Important safety information
NAD⁺ is generally safe when administered as directed, but it may not be appropriate for everyone. Because NAD⁺ influences cellular energy pathways, some individuals may initially experience flushing, warmth, increased heart rate, lightheadedness, or nausea—especially if injected too quickly. These effects typically resolve with slower administration or dose adjustments.
Compounded NAD⁺ should not be used by individuals with a known allergy to NAD⁺ or any ingredient in the formulation. It is not recommended during pregnancy or breastfeeding unless your provider determines otherwise. NAD⁺ may interact with certain medications or underlying metabolic or mitochondrial disorders.
Limitations of use
Compounded NAD⁺ injections have not been evaluated by the FDA and do not have FDA-approved indications. Their safety and efficacy in children or adolescents have not been established. NAD⁺ should not be used in combination with other IV or injectable nutrient therapies unless directed by a licensed medical provider.
Who should not use compounded NAD⁺
Avoid NAD⁺ injections if:
• You have a known allergy to NAD⁺ or similar ingredients
• You are currently pregnant or breastfeeding (unless advised otherwise)
• You have had a previous adverse reaction to NAD⁺ therapy
• Your medical provider instructs you not to use it due to underlying health risks
How NAD⁺ injections are administered
Your provider will outline exactly how to administer your injections. NAD⁺ is typically injected slowly subcutaneously in the abdomen, upper arm, or thigh. Rapid administration may increase side effects such as nausea or flushing.
Inject only the amount prescribed and follow any titration schedule carefully. Do not adjust your dose without approval from your provider.
What to tell your provider before starting NAD⁺
Inform your provider of all medications, supplements, and medical conditions, including:
• Chronic fatigue or adrenal issues
• Mitochondrial or metabolic disorders
• Cardiovascular disease
• Diabetes or blood sugar disorders
• Cancer history
• Thyroid disorders
• Autoimmune conditions
• History of low blood pressure or dizziness
Let your provider know if you use stimulant medications, antidepressants, anti-inflammatory medications, or hormone therapies, as dosage adjustments or monitoring may be needed.
Serious side effects
Serious reactions are rare, but discontinue use and seek medical attention if you experience:
• Difficulty breathing
• Swelling of the face, lips, or throat
• Severe dizziness or fainting
• Rapid heartbeat that does not resolve
• Severe or persistent vomiting
• Chest tightness or severe abdominal pain
Common side effects
Most side effects are mild and temporary, especially during early injections or if the dose is given too quickly. These may include:
• Flushing or warmth
• Temporary nausea
• Lightheadedness
• Mild headache
• Muscle tension
• Tingling sensations
• Temporary injection-site redness
If symptoms persist or worsen, contact your provider.
Side effects may be reported to the FDA at 1-800-FDA-1088.
Before using compounded NAD⁺
Review usage instructions with your provider prior to your first dose. If you have a history of dehydration, low blood pressure, mitochondrial disorders, or chronic illness, your provider may adjust your protocol. Avoid alcohol or recreational substances while using NAD⁺. Use caution when combining NAD⁺ with other metabolic or detoxifying therapies.
How to take NAD⁺ injections
Use NAD⁺ exactly as directed:
• Inject slowly to minimize nausea
• Stay hydrated prior to administration
• Store the medication as instructed by your pharmacy (typically refrigerated)
• Rotate injection sites to reduce irritation
• Contact your provider or poison control if too much is taken
Never share syringes, needles, or multi-dose vials.
Legal and safety disclosures
Compounded NAD⁺ is not FDA-approved. The FDA does not evaluate compounded products for safety, effectiveness, or manufacturing quality. Compounded NAD⁺ products are not affiliated with any brand-name manufacturer of commercial NAD⁺ therapy.
Branched-Chain Amino Acids (BCAA) Safety Information (EVOLVD)
This document provides an overview of important safety considerations related to EVOLVD’s Branched-Chain Amino Acid (BCAA) formulations. BCAAs are categorized as dietary supplements and are not intended to diagnose, treat, cure, or prevent any disease. Dietary supplements are regulated differently from prescription medications and do not undergo FDA approval for safety, effectiveness, or manufacturing standards. Your healthcare provider can help determine whether BCAA supplementation is appropriate for you based on your individual health needs.
This summary does not include all possible safety information and does not replace guidance from your licensed medical provider.
Indications and Use
BCAAs (Leucine, Isoleucine, and Valine) are essential amino acids that may support:
• Muscle recovery following exercise
• Preservation of lean muscle mass during periods of calorie reduction
• Improved energy levels and reduced exercise-related fatigue
• Support for metabolic health and overall vitality
BCAA supplements are commonly used as part of a fitness or wellness routine and may be combined with healthy nutrition and regular physical activity.
BCAAs should not be used as a substitute for medical treatment, balanced diet, or prescribed therapies. Safety and efficacy have not been established for individuals under 18 unless approved by a healthcare professional.
About EVOLVD’s BCAA Formulation
EVOLVD offers a professional-grade BCAA blend designed to support muscle recovery, performance, and overall metabolic health. Our formulation includes:
• A clinically aligned ratio of essential amino acids
• High-quality, third-party-tested ingredients
• A dissolvable powder or capsule format for easy daily use
These components support natural energy production and muscle preservation but do not change the standard safety considerations associated with BCAA supplementation.
Important Safety Information
General Safety Considerations
BCAAs are generally well tolerated; however, certain individuals may require additional caution.
You should not use BCAA supplements if:
• You have a known allergy to any amino acid ingredient
• Your medical provider has advised against increased protein or amino acid intake
• You have a metabolic disorder affecting amino acid processing (e.g., Maple Syrup Urine Disease)
Seek medical advice if you experience:
• Persistent nausea or stomach discomfort
• Significant fatigue
• Mood changes
• New or worsening symptoms during use
Limitations of Use
• BCAAs are not intended to replace prescribed medications or medical treatments
• Not evaluated or approved by the U.S. Food and Drug Administration (FDA)
• Not suitable as a sole source of nutrition
• Not recommended during pregnancy or breastfeeding without provider approval
Who Should Not Use BCAAs
Avoid BCAA supplementation if you:
• Have kidney or liver disease unless cleared by a provider
• Have a metabolic amino-acid disorder
• Are pregnant or breastfeeding without provider oversight
• Are on a protein-restricted diet
• Are sensitive or allergic to supplement ingredients
• Are taking medications that interact with amino acid metabolism
How to Use BCAAs
EVOLVD’s BCAA supplement is taken orally, either as a dissolvable powder or capsule.
General guidance:
• Use exactly as directed on the label or by your provider
• Take consistently before, during, or after exercise
• Maintain adequate hydration
• Do not exceed recommended dosing
Do not modify your dosage without speaking to a healthcare provider.
What to Tell Your Medical Provider Before Starting
Disclose all of the following before using BCAAs:
• Prescription medications
• Over-the-counter supplements
• Protein powders or amino acid blends
• Any history of kidney or liver issues
• Current fitness goals and dietary intake
• Any history of metabolic or autoimmune conditions
Important considerations include:
• Diabetes medications (BCAAs may influence blood glucose)
• Thyroid disorders
• Mood disorders
• High-protein diets or fasting regimens
Provide your complete medical history for safe use.
Pregnancy & Fertility
BCAA supplementation during pregnancy or breastfeeding should only occur under medical supervision.
Safety data in pregnant or nursing individuals is limited.
Most Serious Side Effects
Serious side effects are rare, but seek immediate medical help if you experience:
• Severe allergic reaction (swelling, rash, difficulty breathing)
• Symptoms of kidney strain (low urine output, swelling, severe fatigue)
• Persistent vomiting or gastrointestinal distress
Stop use and contact a provider if you develop:
• Unusual muscle soreness unrelated to exercise
• Severe headaches
• Marked changes in mood or alertness
Common Side Effects
Most side effects are mild and may include:
• Upset stomach or bloating
• Headache
• Mild nausea
• Changes in appetite
• Fatigue
• Muscle soreness
• Digestive discomfort
If symptoms persist or worsen, discontinue use and consult a healthcare provider.
Before Using BCAAs
Review with your provider:
• Any protein or amino-acid restrictions
• Kidney or liver function concerns
• All supplements or performance products you currently take
• Any unusual fatigue or muscle weakness
• Any dietary protocols affecting amino acid intake
Read all product instructions carefully before your first use.
How to Take BCAAs
General administration guidelines:
• Follow recommended dosing instructions
• Take consistently for best results
• Mix with water if using powder
• Store in a cool, dry place
• Keep out of reach of children
Avoid exceeding recommended serving amounts.
Legal and Safety Disclosure
BCAAs are dietary supplements and are not approved by the FDA for the treatment or prevention of disease. Supplements do not undergo the same testing standards or review processes as prescription drugs.
Product names referenced in educational materials belong to their respective owners. EVOLVD is not affiliated with those companies.